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The Sinclair Method is a science-based approach to treating Alcohol Use Disorder (AUD). It involves taking naltrexone, an FDA-approved medication, one hour before drinking alcohol. Naltrexone blocks the endorphins (pleasure hormones) released when drinking, breaking the brain's association between alcohol and pleasure over time. This process, called pharmacological extinction, gradually reduces cravings and compulsive drinking behavior.

Pharmacological extinction is the gradual process by which the brain unlearns the association between alcohol and pleasure. By consistently using naltrexone before drinking, the brain stops reinforcing the rewarding effects of alcohol. Over time, this reduces cravings and compulsive behaviors, leading to a more natural and balanced state similar to the brain’s pre-addicted condition.

TSM is designed for individuals struggling with Alcohol Use Disorder (AUD) who want to reduce or stop drinking. It’s ideal for people ready to try a gradual, evidence-based approach to improving their relationship with alcohol.

The method may not be suitable for: Individuals addicted to opioids, as naltrexone will trigger withdrawal symptoms. Pregnant or breastfeeding individuals (consult a doctor to evaluate risks and benefits). Those with severe liver conditions (consult your doctor to ensure safety, as naltrexone is typically safe at prescribed doses). People using opioid-based painkillers, as naltrexone blocks their effects. Always consult a healthcare provider before starting TSM.

The Sinclair Method combines: Taking naltrexone: One hour before drinking to block the brain’s reward system for alcohol. Behavioral changes: As cravings fade, you can focus on building healthier habits, identifying triggers, and addressing emotional or psychological reasons for drinking. Over time, the brain unlearns compulsive drinking behavior and cravings decrease significantly. Consistency is key.

TSM is referred to as a dual therapy because it addresses: Neurological aspects: By blocking the reward system, naltrexone reduces cravings and breaks the reinforcement cycle of drinking. Behavioral and emotional aspects: As cravings diminish, individuals can focus on triggers, emotional coping mechanisms, and creating healthier habits. This dual approach ensures long-term success, as both the physical and psychological causes of AUD are addressed.

Most people tolerate naltrexone well, but side effects can include nausea, dizziness, and headaches, which are usually mild and temporary. Eating a small meal or drinking water before taking naltrexone often helps. If side effects persist, consult your healthcare provider.

The timeline for results varies: Some people notice changes in their drinking habits within weeks. On average, significant progress is made in 3–6 months. Full extinction of cravings can take up to a year or longer for some individuals. Patience is crucial—it took time to develop the addiction, and it takes time to unlearn it.

Studies show TSM has a success rate of around 78% when followed consistently. It’s most effective when paired with support, such as counseling or peer groups.

We do not recommend starting TSM if you are already abstinent and successfully managing your AUD. TSM is intended for those who continue to struggle with cravings or compulsive drinking.

TSM faces several challenges: Limited awareness among medical professionals: Naltrexone is typically prescribed daily for abstinence, not as part of TSM. Off-label use of the medication for TSM requires more education and advocacy. Stigma around medication-assisted treatments (MAT): Misconceptions about MAT and societal beliefs like "once an alcoholic, always an alcoholic" hinder its acceptance. Dominance of abstinence-based programs: Traditional approaches like the 12-step model discourage drinking entirely, whereas TSM uses a different paradigm. Lack of funding: Little investment has been made to promote TSM despite its proven effectiveness. We are committed to changing this by raising awareness, offering support, and partnering with professionals dedicated to helping people with AUD.